What is Klotho?
Klotho is a transmembrane protein that is found in many tissues throughout the body, including the kidneys, liver, brain, and blood. It is a multifunctional protein that plays a role in a variety of important cellular processes, including:
- Mineral metabolism: Klotho helps to regulate the levels of calcium, phosphate, and vitamin D in the blood. This is important for maintaining bone health and preventing kidney stones.
- Insulin signaling: Klotho interacts with the insulin receptor to enhance insulin sensitivity. This helps to regulate blood sugar levels and protect against diabetes.
- Cell growth and survival: Klotho promotes cell growth and survival by activating several signaling pathways. This is important for maintaining tissue function and protecting against age-related diseases.
- Protection against stress: Klotho has antioxidant and anti-inflammatory properties that help to protect cells from damage. This is important for preventing a variety of diseases, including cardiovascular disease, cancer, and Alzheimer’s disease.
Klotho is important for overall health and longevity.
Studies have shown that mice that are lack Klotho age prematurely and die early. In humans, low levels of Klotho have been associated with accelerating a variety of age-related diseases including osteoporosis, kidney failure, cardiovascular disease, cancer, diabetes, Alzheimer’s disease, autoimmune conditions. Researchers are investigating ways to increase Klotho levels as a potential therapy for these and many other age-related diseases.
Benefits of Klotho:
- Protects against cardiovascular disease: Klotho helps to prevent the buildup of plaque in the arteries and the formation of blood clots. It also helps to improve blood pressure and cholesterol levels.
- Reduces the risk of cancer: Klotho has anti-tumor properties and can help to suppress the growth and spread of cancer cells.
- Improves kidney function: Klotho helps to protect the kidneys from damage and improve their function.
- Strengthens bones: Klotho helps to promote bone formation and reduce bone loss.
- Improves cognitive function: Klotho helps to protect the brain from damage and improve cognitive function in old age.
Overall, Klotho is an important protein that plays a vital role in maintaining health and longevity.