Scientific Articles

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Scientific Articles

Klotho: The protein that could extend your healthspan and lifespan – Click Here

Low Serum Klotho Associated With All-cause Mortality Among a Nationally Representative Sample of American Adults – Click Here

12 Inflammatory Lab Markers – Click Here

The key to better health & fitness is in your gut. – Click Here

In the InCHIANTI study of 1,203 Italian adults, the median (25th–75th percentile) plasma klotho concentration was 676 (530–819) pg/mL. Plasma klotho was correlated with age – Click Here

New Evidence for Biomarkers of Dementia and Value of Aerobic Exercise in Preventing Cognitive Decline – Click Here

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis – Click Here

Anti-inflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. – Click Here

Klotho Depletion Contributes to Increased Inflammation in Kidney – Click Here

Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease – Click Here

The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance – Click Here

Klotho: a link between cardiovascular and non-cardiovascular mortality – Click Here

Klotho Links Inflammation, Salt Sensitivity, Hypertension and Mortality in Aging – Click Here


Is Klotho a Real-Life Fountain of Youth? – Click Here

Find Out if Your Exercise Routine is Improving Your Klotho Level! – Click Here

Know if your exercise is improving your Klotho level! – Click Here

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice – Click Here

NutraKlotho TM Nutraceutical Klotho Supplement – Click Here

Klotho’s Role In Longevity, Intelligence, Muscle Strength, And Cancer – Click Here

Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes. – Click Here

Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury – Click Here

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Klotho Ameliorates Cellular Inflammation via Suppression of Cytokine Release and Upregulation of miR-29a in the PBMCs of Diagnosed Alzheimer’s Disease Patients
Click Here

1. Liu, F., Wu, S., Ren, H. et al. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13, 254–262 (2011).
2. Hui, H., Zhai, Y., Ao, L., Cleveland, J. C., Jr, Liu, H., Fullerton, D. A., & Meng, X. (2017). Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget8(9), 15663–15676.
3. Typiak, M.; Piwkowska, A. Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. Int. J. Mol. Sci. 202122, 956. 
4. Mytych, J.; Sołek, P.; Będzińska, A.; Rusinek, K.; Warzybok, A.; Tabęcka-Łonczyńska, A.; Koziorowski, M. Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. Cells 20209, 261.
5. Bi X, Yang K, Zhang B, Zhao J: The Protective Role of Klotho in CKD-Associated Cardiovascular Disease. Kidney Dis 2020;6:395-406. doi: 10.1159/000509369
6. Martín-Núñez EDonate-Correa JFerri CLópez-Castillo ÁDelgado-Molinos AHernández-Carballo CPérez-Delgado NRodríguez-Ramos SCerro-López PTagua VGMora-Fernández CNavarro-González JFAssociation between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control studyAging (Albany NY)202012:19521964.
7. Wang N, Ma J, Ren Y, Xiang S, Jia R. Secreted klotho from exosomes alleviates inflammation and apoptosis in acute pancreatitis. American Journal of Translational Research. 2019 ;11(6):3375-3383. 
8. Chen, J., Jianglei Chen From the Department of Physiology, Fan, J., Jun Fan From the Department of Physiology, Wang, S., Shirley Wang From the Department of Physiology, . . . Al., E. (2018, March 26). Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1. Retrieved from


9. Gaspar, R. J. (1970, January 01). Klotho: Relevance in the control of neuroinflammation in Parkinson’s disease. Retrieved from


10. Gao, W., Yuan, C., Zhang, J., Li, L., Yu, L., Wiegman, C., . . . Yao, X. (2015, September 18). Klotho expression is reduced in COPD airway epithelial cells: Effects on inflammation and oxidant injury. Retrieved from


11. Izquierdo, M. C., Perez-Gomez, M. V., Sanchez-Niño, M. D., Sanz, A. B., Ruiz-Andres, O., Poveda, J., . . . Ortiz, A. (2012, December 01). Klotho, phosphate and inflammation/ageing in chronic kidney disease. Retrieved from


12. Krick, S., Grabner, A., Baumlin, N., Yanucil, C., Helton, S., Grosche, A., . . . Salathe, M. (2018, July 01). Fibroblast growth factor 23 and Klotho contribute to airway inflammation. Retrieved from


13. Liu, F., Wu, S., Ren, H., & Gu, J. (2011, February 20). Klotho suppresses RIG-I-mediated senescence-associated inflammation. Retrieved from


14. Martín-Núñez, E., Donate-Correa, J., López-Castillo, Á, Delgado-Molinos, A., Ferri, C., Rodríguez-Ramos, S., . . . Navarro-González, J. (2017, October 25). Soluble levels and endogenous vascular gene expression of KLOTHO are related to inflammation in human atherosclerotic disease. Retrieved from


15. Oh, H. J., Nam, B. Y., Lee, M. J., Kim, C. H., Koo, H. M., Doh, F. M., Han, J. H., Kim, E. J., Han, J. S., Park, J. T., Yoo, T.-H., Kang, S.-W., Han, D.-S., & Han, S. H. (2015). Decreased Circulating Klotho Levels in Patients Undergoing Dialysis and Relationship to Oxidative Stress and Inflammation. Peritoneal Dialysis International, 35(1), 43–51.
16. Thurston, R. D., Larmonier, C. B., Majewski, P. M., Ramalingam, R., Midura-Kiela, M., Laubitz, D., . . . Ghishan, F. K. (2009, December 11). Tumor Necrosis Factor and Interferon-γ Down-regulate Klotho in Mice With Colitis. Retrieved from


17. Zhou, X., Chen, K., Lei, H., & Sun, Z. (2015, January 01). Klotho Gene Deficiency Causes Salt-Sensitive Hypertension via Monocyte Chemotactic Protein-1/CC Chemokine Receptor 2–Mediated Inflammation. Retrieved from


18. Zhao, Y., Banerjee, S., Dey, N., LeJeune, W. S., Sarkar, P. S., Brobey, R., . . . Choudhary, S. (2011, July 01). Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation. Retrieved from

Klotho deficiency causes vascular calcification – Click Here

Calcification of coronary arteries and aortic valve and circulating a-klotho levels in patients with chronic kidney disease – Click Here

Klotho and vascular calcification: An evolving paradigm – Click Here

Magnesium prevents vascular calcification in Klotho deficiency – Click Here

The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells – Click Here

Changes in serum FGF23 and Klotho levels and calcification scores of the abdominal aorta after parathyroidectomy for secondary hyperparathyroidism – Click Here

A Decreased Level of Soluble Klotho Can Predict Cardiovascular Death in No or Mild Abdominal Aortic Calcification Hemodialysis Patients – Click Here

The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells – Click Here

αKlotho Regulates Age-Associated Vascular Calcification – Click Here

The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study – Click Here

The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease – Click Here

Brain Neurological Disorders

Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third – Click Here

Gene variant staves off Alzheimer’s in some people – Click Here

Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies – Click Here

Could a Protein Called Klotho Block Dementia and Aging? – Click Here

Klotho: neuroprotective against Alzheimer’s disease – Click Here

Klotho Is a Neuroprotective and Cognition-Enhancing Protein – Click Here

What is Klotho and Can It “Supercharge” the Brain? – Click Here

Klotho Shows Promise for Cognition Brain Enhancement – Click Here

Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents – Click Here

Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study – Click Here

Life Extension Factor Klotho Enhances Cognition – Click Here

Klotho Protein Protects Brains of ALS Mice, Study Suggests – Click Here

Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs – Click Here

Longevity hormone boosts memory and protects against brain aging in mice
Mice treated with klotho do better on tests of memory and motor skill – Click Here

Small-molecule Klotho enhancers as novel treatment of neurodegeneration – Click Here

Brain-Specific Klotho Isoform Fortifies Memory – Click Here

Klotho deficiency affects the spine morphology and network synchronization of neurons – Click Here

Klotho, the Key to Healthy Brain Aging? – Click Here

Klotho protein in neurodegenerative disorders – Click Here

Immune System

Klotho controls the brain-immune system interface – Click Here

Klotho Shields the Brain from the Peripheral Immune System, but Declines with Age – Click Here

Systemic Klotho therapy protects against insulitis and enhances beta-cell mass – Click Here

Klotho protects human monocytes from LPS-induced immune impairment – Click Here

Dental Applications

Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H2O2-Induced Oxidative Stress – Click Here

Involvement of the Klotho Protein in Dentin Formation and Mineralization – Click Here

Muscle Regeneration and Recovery

Klotho Deficiency Causes Heart Aging – Click Here

Study reveals roadmap of muscle decline with age
A comprehensive roadmap of muscle decline with age in mice reveals possible new targets for treatments, including the molecule Klotho – Click Here

Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle – Click Here

Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration – Click Here

Exercise intensity regulates cytokine and klotho responses in men – Click Here

The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function – Click Here

Delivering Klotho to Old Mice Partially Reverses Loss of Muscle Regenerative Capacity – Click Here


A Master Regulator of Cardiovascular Disease – Click Here

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells – Click Here

Addiction and Depression

Soluble Klotho and Brain Atrophy in Alcoholism – Click Here

Soluble α-Klotho in Liver Cirrhosis and Alcoholism – Click Here

Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics – Click Here

This Alcohol Gene Reportedly Controls Your Consumption – Click Here

A Gene Might Affect How Much You Drink – Click Here

A “TeeTotaler” Gene Discovery Could Lead to Alcohol Addiction Drinking Treatments – Click Here

Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression – Click Here

Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies – Click Here

Klotho at the Edge of Alzheimer’s Disease and Senile Depression – Click Here

Peripheral levels of the anti-aging hormone Klotho in patients with depression – Click Here

Longevity hormone is lower in stressed, depressed women – Click Here

Longevity factor klotho and chronic psychological stress – Click Here

Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression – Click Here

Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder – Click Here

Klotho Gene: Anti-aging superpowers? – Click Here

Klotho May Hold the Key to Reducing Negative Stress Effects on Health – Click Here

Klotho Addiction – Click Here

Klotho Depression – Click Here

Klotho and Hair Regeneration

Klotho & Hair – Click Here

Klotho Dementia

Klotho Dementia – Click Here

Klotho Hypertension

Klotho Hypertension – Click Here