Scientific Articles
See our related articles
Scientific Articles
Klotho: The protein that could extend your healthspan and lifespan – Click Here
Low Serum Klotho Associated With All-cause Mortality Among a Nationally Representative Sample of American Adults – Click Here
12 Inflammatory Lab Markers – Click Here
The key to better health & fitness is in your gut. – Click Here
In the InCHIANTI study of 1,203 Italian adults, the median (25th–75th percentile) plasma klotho concentration was 676 (530–819) pg/mL. Plasma klotho was correlated with age – Click Here
New Evidence for Biomarkers of Dementia and Value of Aerobic Exercise in Preventing Cognitive Decline – Click Here
Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis – Click Here
Anti-inflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. – Click Here
Klotho Depletion Contributes to Increased Inflammation in Kidney – Click Here
Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease – Click Here
The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance – Click Here
Klotho: a link between cardiovascular and non-cardiovascular mortality – Click Here
Klotho Links Inflammation, Salt Sensitivity, Hypertension and Mortality in Aging – Click Here
INFLAMMATION AND FGF23/KLOTHO SYSTEM IN ATHEROSCLEROSIS – Click Here
Is Klotho a Real-Life Fountain of Youth? – Click Here
Find Out if Your Exercise Routine is Improving Your Klotho Level! – Click Here
Know if your exercise is improving your Klotho level! – Click Here
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice – Click Here
NutraKlotho TM Nutraceutical Klotho Supplement – Click Here
Klotho’s Role In Longevity, Intelligence, Muscle Strength, And Cancer – Click Here
Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes. – Click Here
Ginseng increases Klotho expression by FoxO3-mediated manganese superoxide dismutase in a mouse model of tacrolimus-induced renal injury – Click Here
Related Products
HealthSpan – Click Here
Enclomiphene Protocol – Click Here
OneTest for Cancer – Click Here
MitoQ – Click Here
Lets get checked – Click Here
Nutrafol – Click Here
Longevity Collection – Click Here
The DNA Company – Click Here
My Plenity – Click Here
Athletic Greens – Click Here
NovosLab – Click Here
NovaaLab – Click Here
Elo Health – Click Here
Lifepharm – Click Here
Ourovitae – Click Here
Nootopia – Click Here
Ombre Lab – Click Here
OneSkin – Click Here
ourovitae – Click Here
lumen – Click Here
Can This Red Algae Be The Secret To HALTING The Rapid-Aging Process? – Click Here
Pure NAD+ Nasal Spray – Click Here
Senolytic Complex – Click Here
Advanced Bionutritionals – Click Here
CRP Test – Click Here
Micro Nutrient Test – Click Here
Vinia – Click Here
dvelop immunity – Click Here
Coast Drink – Click Here
Rootine – Click Here
Elo Health – Click Here
Celluma Light Therapy – Click Here
Jinfiniti – testing your NAD levels at home and beyond – Click Here
BEACON40® Personal – Click Here
GROQ Health – Click Here
CELLULAR REPAIR EYE SERUM – Click Here
A Breakthrough in Testosterone Optimization – Click Here
Aurum Capsules – Click Here
Juvenescense – Click Here
SuperBeets
Memory & Focus – Click Here
Cortisol Test – Click Here
PHOSPHORUS – Click Here
Alive by Science – Click Here
Elo Health – Click Here
Fountain TRT – Click Here
Hone – Click Here
MyChon – Click Here
Sollice Biotech – Click Here
Life Extension – Click Here
Organic India Tulsi Herbal Supplement – Click Here
HPN NAD+ Booster (NAD3) – Click Here
Hormone Replacement Therapy (HRT) for Men – Click Here
Precision Probiotics + Prebiotics with Viome’s Gut Intelligence™ Test – Click Here
Coast Drink – Click Here
Timeline Nutrition – Click Here
Gut Intelligence Test – Click Here
The DNA Company – Click Here
GENIUS ETERNAL – Click Here
Biological Age Test – Click Here
Self Decode – Click Here
Bio Pro – Click Here
Trio Cosmetic – GHK-cu, Argireline, Leuphasyl – Click Here
Inflammation
Klotho Ameliorates Cellular Inflammation via Suppression of Cytokine Release and Upregulation of miR-29a in the PBMCs of Diagnosed Alzheimer’s Disease Patients
– Click Here
1. Liu, F., Wu, S., Ren, H. et al. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol 13, 254–262 (2011). https://doi.org/10.1038/ncb21672. Hui, H., Zhai, Y., Ao, L., Cleveland, J. C., Jr, Liu, H., Fullerton, D. A., & Meng, X. (2017). Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget, 8(9), 15663–15676. https://doi.org/10.18632/oncotarget.149333. Typiak, M.; Piwkowska, A. Antiinflammatory Actions of Klotho: Implications for Therapy of Diabetic Nephropathy. Int. J. Mol. Sci. 2021, 22, 956. https://doi.org/10.3390/ijms220209564. Mytych, J.; Sołek, P.; Będzińska, A.; Rusinek, K.; Warzybok, A.; Tabęcka-Łonczyńska, A.; Koziorowski, M. Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. Cells 2020, 9, 261. https://doi.org/10.3390/cells90202615. Bi X, Yang K, Zhang B, Zhao J: The Protective Role of Klotho in CKD-Associated Cardiovascular Disease. Kidney Dis 2020;6:395-406. doi: 10.1159/0005093696. . Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study. Aging (Albany NY). 2020; 12:1952–1964. https://doi.org/10.18632/aging.1027347. Wang N, Ma J, Ren Y, Xiang S, Jia R. Secreted klotho from exosomes alleviates inflammation and apoptosis in acute pancreatitis. American Journal of Translational Research. 2019 ;11(6):3375-3383.
Calcification
Klotho deficiency causes vascular calcification – Click Here
Calcification of coronary arteries and aortic valve and circulating a-klotho levels in patients with chronic kidney disease – Click Here
Klotho and vascular calcification: An evolving paradigm – Click Here
Magnesium prevents vascular calcification in Klotho deficiency – Click Here
The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells – Click Here
Changes in serum FGF23 and Klotho levels and calcification scores of the abdominal aorta after parathyroidectomy for secondary hyperparathyroidism – Click Here
A Decreased Level of Soluble Klotho Can Predict Cardiovascular Death in No or Mild Abdominal Aortic Calcification Hemodialysis Patients – Click Here
The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells – Click Here
αKlotho Regulates Age-Associated Vascular Calcification – Click Here
The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study – Click Here
The Clinical Value of Klotho and FGF23 in Cardiac Valve Calcification Among Patients with Chronic Kidney Disease – Click Here
Brain Neurological Disorders
Klotho Variant Cuts ApoE4’s Alzheimer Risk by a Third – Click Here
Gene variant staves off Alzheimer’s in some people – Click Here
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies – Click Here
Could a Protein Called Klotho Block Dementia and Aging? – Click Here
Klotho: neuroprotective against Alzheimer’s disease – Click Here
Klotho Is a Neuroprotective and Cognition-Enhancing Protein – Click Here
What is Klotho and Can It “Supercharge” the Brain? – Click Here
Klotho Shows Promise for Cognition Brain Enhancement – Click Here
Low serum klotho concentration is associated with worse cognition, psychological components of frailty, dependence, and falls in nursing home residents – Click Here
Plasma Klotho and Cognitive Decline in Older Adults: Findings From the InCHIANTI Study – Click Here
Life Extension Factor Klotho Enhances Cognition – Click Here
Klotho Protein Protects Brains of ALS Mice, Study Suggests – Click Here
Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs – Click Here
Longevity hormone boosts memory and protects against brain aging in mice
Mice treated with klotho do better on tests of memory and motor skill – Click Here
Small-molecule Klotho enhancers as novel treatment of neurodegeneration – Click Here
Brain-Specific Klotho Isoform Fortifies Memory – Click Here
Klotho deficiency affects the spine morphology and network synchronization of neurons – Click Here
Klotho, the Key to Healthy Brain Aging? – Click Here
Klotho protein in neurodegenerative disorders – Click Here
Immune System
Klotho controls the brain-immune system interface – Click Here
Klotho Shields the Brain from the Peripheral Immune System, but Declines with Age – Click Here
Systemic Klotho therapy protects against insulitis and enhances beta-cell mass – Click Here
Klotho protects human monocytes from LPS-induced immune impairment – Click Here
Dental Applications
Recombinant Klotho Protects Human Periodontal Ligament Stem Cells by Regulating Mitochondrial Function and the Antioxidant System during H2O2-Induced Oxidative Stress – Click Here
Involvement of the Klotho Protein in Dentin Formation and Mineralization – Click Here
Muscle Regeneration and Recovery
Klotho Deficiency Causes Heart Aging – Click Here
Study reveals roadmap of muscle decline with age
A comprehensive roadmap of muscle decline with age in mice reveals possible new targets for treatments, including the molecule Klotho – Click Here
Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle – Click Here
Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration – Click Here
Exercise intensity regulates cytokine and klotho responses in men – Click Here
The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function – Click Here
Delivering Klotho to Old Mice Partially Reverses Loss of Muscle Regenerative Capacity – Click Here
THE EFFECT OF ELECTRICAL STIMULATION ON AGED SKELETAL MUSCLE REGENERATIVE POTENTIAL – Click Here
Klotho
A Master Regulator of Cardiovascular Disease – Click Here
Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells – Click Here
Addiction and Depression
Soluble Klotho and Brain Atrophy in Alcoholism – Click Here
Soluble α-Klotho in Liver Cirrhosis and Alcoholism – Click Here
Alpha Klotho and Fibroblast Growth Factor-23 Among Alcoholics – Click Here
This Alcohol Gene Reportedly Controls Your Consumption – Click Here
A Gene Might Affect How Much You Drink – Click Here
A “TeeTotaler” Gene Discovery Could Lead to Alcohol Addiction Drinking Treatments – Click Here
Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression – Click Here
Could α-Klotho Unlock the Key Between Depression and Dementia in the Elderly: from Animal to Human Studies – Click Here
Klotho at the Edge of Alzheimer’s Disease and Senile Depression – Click Here
Peripheral levels of the anti-aging hormone Klotho in patients with depression – Click Here
Longevity hormone is lower in stressed, depressed women – Click Here
Longevity factor klotho and chronic psychological stress – Click Here
Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression – Click Here
Klotho Gene and Selective Serotonin Reuptake Inhibitors: Response to Treatment in Late-Life Major Depressive Disorder – Click Here
Klotho Gene: Anti-aging superpowers? – Click Here
Klotho May Hold the Key to Reducing Negative Stress Effects on Health – Click Here
Klotho Addiction – Click Here
Klotho Depression – Click Here
Klotho and Hair Regeneration
Klotho & Hair – Click Here
Klotho Dementia
Klotho Dementia – Click Here
Klotho Hypertension
Klotho Hypertension – Click Here
